Prolotherapy, PRP

Prolotherapy, PRP

Prolotherapy, PRP (Platelet Rich Plasma) and Stem Cell are injectable solutions used in Cellular Regenerative Medicine to stimulate our own bodies’ capacities to heal tissue damage. These injections stimulate a cellular rehabilitative process for injuries to joints, ligaments and tendons. Dr. Turzo uses dextrose (sugar) and lidocaine as a natural irritant to stimulated regeneration with prolotherapy. The substance used for PRP is the patient’s own platelets. The patient’s blood is drawn in office and platelets are concentrated via a centrifuge. The platelets are then injected into the area of injury and or degeneration. Stem cell therapy adds a small amount of fat cells, which contain growth factors to the PRP solution to
enhance the healing process. An evaluation by a physician using regenerative medicine techniques is needed to determine which level of injectable solutions is necessary.
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What is the difference between a cortisone injection and cellular regenerative injections?

Cortisone injections are used to decrease the inflammation of an injury but does not heal the underlying etiology the inflammation. Prolotherapy/PRP and stem cell injections active the patient’s cellular regenerative healing process to repair the damaged tissue thus healing the underling etiology of the inflammation. The use of cortisone in musculoskeletal injuries is controversial and the subject of various studies over the years. In February 2010, researchers in the Netherlands published the results of a well designed, two year randomized controlled blinded trial with a significant test group of 100 patients, comparing corticosteroid use to an injection of concentrated
platelet rich plasma without ultrasound guidance. The PRP injection was given to the lateral epicondyle area of “maximum tenderness,” and a “peppering” technique was used in order to activate the thrombin release from the tendon- in this case endogenous thrombin is the activator for the injected platelet growth factors. The researchers indicate the importance of the “inflammation” phase the first two days post treatment) during which there is a migration of macrophages to the injured tissue site.

Macrophages release additional growth factors, and there is increased collagen synthesis on days three to five. The conclusion of the Netherlands study was that
“PRP reduces pain and significantly increases function, exceeding the effect of the corticosteroid injection.” Dr. Turzo has been treating musculoskeletal dysfunctions and injuries with regenerative medicine since 2000. The office provides the service of prolotherapy and PRP. Dr. Turzo refers to Dr. Donna Alderman DO, her mentor in cellular regeneration for Stem Cell Therapy.

The integrity of the temporal mandibular joint is a commonly missed link in treatment for craniofacial dysfunction. Dentist will offer a mandibular splint to stabilize the joint but PRP with a mandibular splint will repair the injury to the joint. The osteopathic physician will treat the cranial dysfunction, which is essential but the stability of the joint may need specific treatment with PRP to repair the damage to the joint. An essential aspect of treating craniofacial dysfunction is the integrity of the TMJ.


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